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2,530 papers
Xing Su San and Sang Xing Tang attenuate PM2.5-induced upregulation of RAGE, S100A9 and NF-κB in rat lung tissue in a pattern-specific manner, providing preliminary evidence warranting further mechanistic validation.
Rab GTPase Y2H Interactome — Verified Hit DatasetThis dataset contains the curated set of protein-protein interactions identified in a yeast two-hybrid (Y2H) screen against 36 human Rab GTPases, each tested in both nucleotide-locked conformations: GTP-bound (constitutively active, Q→L mutant) and GDP-bound (dominant-ne...
Citri reticulatae pericarpium (CP), the dried peel of Citrus reticulata Blanco (Rutaceae), is a common traditional Chinese medicine and edible material with effects of regulating Qi, strengthening the spleen, and resolving phlegm. While its flavonoids have been extensively studied, the polysaccharides, which are the ma...
This Pearl synthesizes recent advancements in understanding of viral CDN-degrading nucleases and emphasizes three key themes: there is the conservation of CDN signaling mechanisms across different biological domains, structural protein folds are conserved, and structural protein folds are conserved, allowing for functi...
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A hybrid framework that leverages high-throughput molecular assays and active learning to quantify biological properties across evolutionary space and provides a general strategy for building predictive models that better capture the diversity of natural sequence-to-function relationships is presented.
INFORMATION-DYNAMICS MODEL OF PROTEIN-TEMPLATED DNA SYNTHESIS Computational companion for a theoretical study of the bacterial anti-phage reverse transcriptase Drt3b, which synthesizes strictly alternating poly(AC) DNA without any nucleic acid template. BACKGROUND In 2026, Dr. Pujuan Deng et al. (Science) reported that...
Abstract Summarizing a collection P of related RNA secondary structures is a key challenge in applications like evolutionary analysis, alternative fold studies and mRNA vaccine design. This requires both clustering the input structures into similar groups and identifying the core structural motifs on which they agree o...
GHKL ATPases share a unique Bergerat ATP-binding fold and regulate diverse biological processes through ATP-dependent conformational changes. An early step of ATP hydrolysis in this family has been attributed to a single highly conserved glutamate residue proposed to function as the general base. However, mutations of...
The studies were conducted in 2023-2025 to identify naked oat lines bred at the Nemchinovka Federal Research Centre that combine high productivity, grain quality, and adaptability to the conditions of the Kursk region on typical chernozem. The work was carried out in competitive variety trials (randomized blocks, 6-fol...
Photorespiration links carbon metabolism with nitrogen assimilation in C3 plants, but its relationship with nitrogen productivity in perennial turfgrass remains unclear. Ten Kentucky bluegrass (Poa pratensis L.) cultivars were screened for photorespiration rate and intensity. ‘Heidi’ and ‘My Holiday’ exhibited the high...
In conclusion, Panax ginseng may have protective effect on AlCl₃-induced liver, kidney, and testicular toxicity.
Multiomics and structural in silico analyses of publicly available experimental genomic, transcriptomic, and proteomic datasets are performed, combined with structural modeling, to investigate the glycosylation pathway of the medically important snake B. jararaca, suggesting that the glycosylation machinery is coupled...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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