These curves describe an uncomplicated course rather than validated diagnostic thresholds; they provide a shoulder-specific normative reference and ESR trajectory for RSA, and a benchmark for future infection-event cohorts.
Jaemin Lee, S. Yang, Doo-Sup Kim· Diagnostics· 0 citations
Infant-associated bifidobacteria utilize lacto-N-biose I (LNB) and galacto-N-biose (GNB), major components of human milk oligosaccharides and intestinal mucin, respectively, through the GNB/LNB metabolic pathway. A UDP-glucose–hexose-1-phosphate uridylyltransferase (GalT) from Bifidobacterium longum JCM 1217 (BlGalT2)...
M. Sato, C. Yamada, M. Nishimoto et al.· bioRxiv· 0 citations
Abstract The circadian clock enables organisms to align internal daily rhythms with environmental cues, with major consequences for survival and fitness. Although the molecular framework of this system in Drosophila melanogaster is well characterized through transcription translation feedback loops involving ten core c...
Maya Yair, Bettina Fishman, Maya Aslan et al.· Heredity· 0 citations
Findings indicate that while protein–protein interactions may initiate LLPS, m6A-modulated RNA–protein interactions govern condensate growth and stability, and provide a mechanistic insight into how epitranscriptomic modifications regulate biomolecular condensation and influence cellular organization, gene regulation,...
Chamali Thalagaha Mudiyanselage, Milan Pandey, Sudeshi M. Abedeera et al.· ACS Bio & Med Chem Au· 0 citations
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This study provides a systematic evaluation of engineering strategies targeting the unique constraints of very small peptide secretion in K. phaffii, and identifies genetic targets and mechanistic insights that serve as a starting point for cargo-specific optimization efforts and highlight the unique challenges that sh...
Johanna Pirchner, Simon Arhar, Corinna Odar et al.· Frontiers in Bioengineering...· 0 citations
BACKGROUND
The pea aphid, Acyrthosiphon pisum, is a damaging phloem-feeding pest of legume crops, and RNA interference (RNAi)-based targeting of stress-adaptation genes offers a promising route for target-specific pest management. Apolipoprotein D (ApoD) proteins are putative lipid carriers in insects, but the function...
Bing-Jin Wu, Xia Yang, S. Mobarak et al.· Pest Management Science· 0 citations
The discovery and characterization of a novel thermophilic 3-quinuclidinone reductase identified through metagenomic mining of hot spring environments establishes ScQR as a robust biocatalyst for high-temperature pharmaceutical applications and demonstrates a scalable workflow for optimizing enzymes from extreme enviro...
D. Lou, Jing-Hao Cui, Jing-Fa Duan et al.· Applied and Environmental Mi...· 0 citations
Genetic polymorphism of milk proteins, particularly the presence of the κ-casein E variant, significantly modulates the pro-inflammatory potential of milk digests in sensitized lymphocytes, suggesting new strategies for reducing milk immunogenicity.
L. Markiewicz, Dagmara Złotkowska, A. Ogrodowczyk et al.· Nutrients· 0 citations
Enhancing the robustness of functional proteins remains a central challenge in biotechnology, with implications for catalysis, pharmaceuticals, and industrial synthesis. Enzyme immobilization in porous materials such as metal–organic frameworks (MOFs) is widely used to enhance enzyme stability; however, the structural...
Siene Swinnen, Maxim Lox, Marika Di Berto Mancini et al.· Journal of the American Chem...· 0 citations
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (CRPC) driven by therapy-induced lineage plasticity. While endoplasmic reticulum (ER) homeostasis is critical for cell fate determination and therapeutic response, the molecular mechanisms linking ER stress regulation to l...
Youjian Li, Yongshan Li, Shiyu Li et al.· Cellular and Molecular Life...· 0 citations
This review systematically compares the evidence for cumulative and interactive effects of heavy metal mixtures across four major neurodegenerative diseases, asking which metal combinations have been directly documented for each disease, and whether these patterns are disease-specific or shared.
I. Mitu, I. Caba, I. Macovei· Journal of Xenobiotics· 0 citations
This study demonstrates that combining internal symmetry analysis and ASR for the ZIP family facilitates elucidation of the metal translocation mechanism and identification of subfamily‐specific features that regulate transport function.
Yao Zhang, Tian-Qi Wang, Hong-Yan Zhao et al.· Protein Science· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
