C-reactive protein (CRP) is a crucial biomarker of inflammation and a primary pattern recognition molecule of the innate immune system. It is predominantly synthesized by hepatocytes and subsequently released into the circulation. The concentration of CRP in plasma can increase significantly, sometimes by up to a tho...
Bin Cheng, Zhi-Xin Yao, Guo-Qiang Wu· Frontiers in Immunology· 0 citations
Single-molecule techniques provide exceptional resolution of biomolecular dynamics but are limited by low throughput. Here, we present a DNA barcoding strategy that enables parallel kinetic profiling of multiple protein variants in a single experiment. Each protein is covalently linked to a unique DNA barcode, decode...
Stefan H. Mueller, David M. Grimson, H. Paz et al.· Nature Communications· 0 citations
Microplastic pollution is an emerging environmental concern that induces oxidative stress, inflammation, and cellular injury in aquatic organisms. Despite increasing evidence of microplastic toxicity, effective mitigation strategies remain limited. This study investigated the protective effects of a chitosan-based nano...
Abdulelah Alabdulwahed, Janin Saadi, Khalil Younis et al.· International Journal of Dru...· 0 citations
Ewing sarcoma (EwS) is an aggressive malignancy of children, adolescents, and young adults driven by the EWS::FLI1 fusion oncoprotein with few effective treatment options in the relapsed or refractory setting. We validate six transmembrane epithelial antigen of the prostate 1 (STEAP1) as a fusion-regulated and clinic...
Tau assembles into fibrillar aggregates that are pathological hallmarks of a group of neurodegenerative diseases collectively called tauopathies. Templated aggregation of naïve tau to seeding-competent fibrils that proceed from cell to cell is a key driver of prion-like progression of tauopathies. This study tests the...
Chung-Ta Han, Karen Tsay, Samuel Lobo et al.· Proceedings of the National...· 0 citations
Messenger RNA (mRNA) therapeutics offer a versatile platform for protein production, but preserving mRNA during delivery remains a major challenge. Here, we report that co-delivery of nucleotides with lipid nanoparticle (LNP)-formulated mRNA significantly enhances translation efficiency across multiple cell types. Syst...
Xuanyu Li, Zhiliang Qin, Yao Chen et al.· Nano Today· 0 citations
Near-term quantum devices remain constrained by limited qubit counts, noise, and shallow circuit depth, restricting their direct application to peptide folding. This work addresses this limitation through a hybrid quantum–classical framework that separates global contact-space exploration from local configuration-space...
Denervation-induced muscle disuse is accompanied by transcriptional remodeling, but ion-channel-related transcripts and accompanying microRNA responses remain incompletely characterized. This research note examined whether
Kcnk5
and mmu-miR-23a-3p are co-altered in a mouse tibialis anterior denervation model...
Gaku Oguri, Takafumi Nakajima, Haruka Ugawa et al.· BMC Research Notes· 0 citations
This deposit presents the complete V3 Architecture, a unified theoretical framework that replaces statistical estimation and empirical approximation with sequential deterministic calculation and formally proven invariants. The V3 Architecture rests on seven absolute invariants:1. Volumetric density: 1026.0 kg/m³ (the a...
outail benhadid· Zenodo (CERN European Organi...· 0 citations
Biomolecular condensates formed by multidomain proteins are increasingly linked to disease and are emerging targets for chemical modulation. Yet most molecular models emphasize intrinsically disordered regions (IDRs), whereas many available ligands bind folded-domain pockets. How IDR modifications and folded-domain lig...
Abstract Molecular dynamics simulations provide detailed trajectories at the atomic level, but extracting interpretable and robust insights from these high-dimensional data remains challenging. In practice, analyses typically rely on a single representation. Here, we show that representation choice is not neutral: it f...
Giottonini Axel, Thomas Lemmin· Communications Chemistry· 0 citations
Endoplasmic reticulum (ER) oxidoreductases are promising targets for host-targeted antiviral agents (HTAs) because of their essential role in protein folding, including the maturation of viral proteins. Human protein disulfide isomerase family member A3 (PDIA3) is involved in the folding of N-glycosylated client prot...
G. Bononi, G. Sibille, Erika Plicanti et al.· Journal of Medicinal Chemist...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
