This work demonstrates that necrotrophic pathogenesis in B. cinerea does not depend on a few primary virulence determinants, but rather on a highly redundant network of host damaging factors.
N. Safari, P. Pattar, M. Magomedov et al.· bioRxiv· 0 citations
A large number of DHF proteins featuring a high or very high degree of identity with the amino acid sequences of both histones H3 and H4 are identified, which constitute a new class of eukaryotic DHF proteins.
Anna Ranaudo, Toshiko Miyake, Haidi Shehi et al.· ACS Omega· 0 citations
Findings identify a novel PRDX1-PRMT5 axis that activates Wnt/β-catenin signaling, highlighting a potential therapeutic strategy for CRC by targeting this pathway to suppress tumor progression and remodel the immune microenvironment.
Nianhua Yu, Xi Li, Jin-Li Han et al.· International Journal of Bio...· 0 citations
The solution structure of mature Saccharomyces cerevisiae Mba1 is determined using multidimensional nuclear magnetic resonance (NMR) spectroscopy and reveals a compact α + β fold with a central hydrophobic cavity and distinct charged surface regions, providing a structural framework for interpreting previous functional...
Jing Yang, Mao-Sen Ruan, Dong-Shuai Bai et al.· Journal of Structural Biolog...· 0 citations
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These findings demonstrate that the conformational plasticity of HOP can be strategically exploited for targeted protein-protein interaction (PPI) disruption in cancer therapy.
Gagandeep Singh, T. Chaudhuri· Biochimica et Biophysica Act...· 0 citations
This study investigated the potential use of hemp seed oil-carnauba wax oleogel as a margarine substitute in crackers and the effects of substituting wheat flour with hemp seed flour. Characterization revealed that 11% wax oleogel best mimicked margarine. Control crackers contained margarine (C1) and oleogel (C2). Whea...
FPCct appears to act like a physiological suppressor of cystogenic signaling, as found in healthy kidney epithelia, that is essential for maintaining epithelial homeostasis.
F. Hassan, Susanne T. Hahnenstein, A. Kraus et al.· American Journal of Physiolo...· 0 citations
The crystal structure of AcrIIA17 is presented and its mechanism of Staphylococcus aureus Cas9 (SauCas9) inhibition is elucidated, identifying AcrIIA17 as an Acr protein that targets the Cas9 BH domain and reveal the BH domain as a regulatory checkpoint in Cas9 activation.
G. Kim, Hyo Been Jin, Yong-Jun Kang et al.· iScience· 0 citations
The metabolic phenotypes were explored in a primary care T2DM cohort, supporting their reproducibility across clinical settings and vitamin D status varied by phenotype severity, with more severe phenotypes more likely to exhibit insufficiency.
L. V. Pires, Matheus Menezes-Santos, Andréa Costa Goes et al.· Diabetes, obesity and metabo...· 0 citations
BgtH12 is established as a critical virulence factor that suppresses basal immunity to promote Bgt colonization and stable overexpression of BgtH12 in wheat enhanced susceptibility.
This case highlights the importance of continued endoscopic surveillance for gastric carcinogenesis even after long‐term clinical remission of MD and reveals no evidence of active MD.
Takaaki Shamoto, Hideko Yamamoto, Takehito Naito et al.· DEN Open· 0 citations
Findings demonstrates that optimized pretreatment coupled with selected indigenous bacterial isolates enhanced conversion of WB into protein-enriched microbial biomass, providing a basis for further development of lignocellulosic biomass valorization for SCP production.
Sharda Devi Rajput, S. Keshavkant· Biomass Conversion and Biore...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.