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protein folding

2,623 papers

#protein folding Open access Aug 2026

Multi-knockout of 29 phytotoxic proteins and metabolites does not completely abolish virulence of the necrotrophic fungus Botrytis cinerea

This work demonstrates that necrotrophic pathogenesis in B. cinerea does not depend on a few primary virulence determinants, but rather on a highly redundant network of host damaging factors.

N. Safari, P. Pattar, M. Magomedov et al. · 0 citations
#protein folding Open access Aug 2026

Novel Eukaryotic Double Histone Fold Motifs Sharing High Sequence Identity with Histones H3 and H4 in Single-Domain Proteins and in Proteins Featuring Remarkable Histone Fold Multiplets

A large number of DHF proteins featuring a high or very high degree of identity with the amino acid sequences of both histones H3 and H4 are identified, which constitute a new class of eukaryotic DHF proteins.

Anna Ranaudo, Toshiko Miyake, Haidi Shehi et al. · 0 citations
#protein folding Aug 2026

PRDX1 drives colorectal cancer progression and immune microenvironment remodeling by facilitating PRMT5 nuclear translocation to activate Wnt/β-catenin signaling.

Findings identify a novel PRDX1-PRMT5 axis that activates Wnt/β-catenin signaling, highlighting a potential therapeutic strategy for CRC by targeting this pathway to suppress tumor progression and remodel the immune microenvironment.

Nianhua Yu, Xi Li, Jin-Li Han et al. · 0 citations
#protein folding Aug 2026

Structural basis of Saccharomyces cerevisiae Mba1 in mitochondrial co-translational membrane insertion.

The solution structure of mature Saccharomyces cerevisiae Mba1 is determined using multidimensional nuclear magnetic resonance (NMR) spectroscopy and reveals a compact α + β fold with a central hydrophobic cavity and distinct charged surface regions, providing a structural framework for interpreting previous functional...

Jing Yang, Mao-Sen Ruan, Dong-Shuai Bai et al. · 0 citations
#protein folding Aug 2026

Characterization of hemp seed oil-carnauba wax oleogel and the effect of oleogel usage and hemp seed flour substitution on the properties of wheat flour crackers.

This study investigated the potential use of hemp seed oil-carnauba wax oleogel as a margarine substitute in crackers and the effects of substituting wheat flour with hemp seed flour. Characterization revealed that 11% wax oleogel best mimicked margarine. Control crackers contained margarine (C1) and oleogel (C2). Whea...

Fundagül Erem, Mukarrem Kırşanu, Emine Yılmaz Can · 0 citations
#protein folding Open access Aug 2026

Structural insights into Cas9 inhibition by AcrIIA17 via bridge helix interaction

The crystal structure of AcrIIA17 is presented and its mechanism of Staphylococcus aureus Cas9 (SauCas9) inhibition is elucidated, identifying AcrIIA17 as an Acr protein that targets the Cas9 BH domain and reveal the BH domain as a regulatory checkpoint in Cas9 activation.

G. Kim, Hyo Been Jin, Yong-Jun Kang et al. · 0 citations
#protein folding Open access Aug 2026

Exploratory Analysis of Type 2 Diabetes Mellitus Metabolic Phenotypes and Their Association With Vitamin D Status in Primary Care Patients

The metabolic phenotypes were explored in a primary care T2DM cohort, supporting their reproducibility across clinical settings and vitamin D status varied by phenotype severity, with more severe phenotypes more likely to exhibit insufficiency.

L. V. Pires, Matheus Menezes-Santos, Andréa Costa Goes et al. · 0 citations
#protein folding Open access Aug 2026

Early Gastric Cancer Detected During 15‐year Surveillance After Ménétrier Disease Remission and Successfully Treated With Endoscopic Submucosal Dissection: A Case Report

This case highlights the importance of continued endoscopic surveillance for gastric carcinogenesis even after long‐term clinical remission of MD and reveals no evidence of active MD.

Takaaki Shamoto, Hideko Yamamoto, Takehito Naito et al. · 0 citations
#protein folding Aug 2026

Bioconversion of wheat bran into protein-enriched single-cell biomass

Findings demonstrates that optimized pretreatment coupled with selected indigenous bacterial isolates enhanced conversion of WB into protein-enriched microbial biomass, providing a basis for further development of lignocellulosic biomass valorization for SCP production.

Sharda Devi Rajput, S. Keshavkant · 0 citations

From tech blogs

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Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

MIT News · Artificial Intelligence Aug 27, 2026

Looking beyond natural sequences

A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.

Google DeepMind Blog Nov 25, 2025

AlphaFold: Five years of impact

Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.

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