Hepatocellular carcinoma (HCC) is characterized by extensive molecular heterogeneity, yet changes in protein abundance alone may not fully capture the regulatory alterations that drive tumor biology. Here, we performed integrated whole-proteome and phosphoproteome profiling of paired HCC and adjacent non-tumorous liver...
Shafaq Saleem, M. Sajid, Rency S. Varghese et al.· International Journal of Mol...· 0 citations
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1s), collectively known as group 1 innate lymphoid cells (ILCs), are critical mediators of anti-tumor immunity, yet their role in brain metastasis remains poorly defined. Using single-cell RNA sequencing and functional depletion models, we show that group 1...
Timothy P McMullen, Pascal Naef, Erika Zagni et al.· bioRxiv (Cold Spring Harbor...· 0 citations
The construction of physical shelters represents a widespread survival strategy among insects. This study evaluated the effect of silk web removal on the efficacy of Beauveria bassiana treatment against Hyphantria cunea larvae. Results indicated that the removal of silk webs significantly increased larval mortality and...
Hong Jiang, Peng Li, Ying Wang et al.· Insects· 0 citations
Circular RNA is a therapeutically promising RNA modality with superior stability and extended protein expression relative to linear RNA. While delivery systems for linear RNA have received much attention, less effort has been directed toward the delivery of circular RNA, whose closed topology and physicochemical prop...
Adam Cook, P. Yadav, Ekram W. Helmy et al.· Journal of the American Chem...· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Retinoblastoma protein (pRb) is a critical tumor suppressor that regulates the cell cycle and maintains genetic stability. While mutations in the retinoblastoma 1(RB1) gene are well-documented in gastric adenocarcinoma (GAC) and hepatocellular carcinoma (HCC), the genomic landscape in Middle Eastern populations remains...
B. Yousif, D. Mahmood· Journal of Advanced Biotechn...· 0 citations
Production of glycoconjugate vaccines has long relied upon chemical methods which are highly complex and expensive, resulting in vaccines that are not widely affordable. Heterologous bioconjugation methods, such as Protein-Glycan Coupling Technology (PGCT), have emerged as a path to significantly cheaper manufactur...
Mark A. Harrison, Tom L. Flood, Mark Reglinski et al.· Communications Biology· 0 citations
EnzymeOS v2.0 is a cloud-native computational protein engineering and biophysical simulation platform engineered to bridge predictive deep-learning fold predictions with real-world wet-lab viability, IP protection, and evolutionary variant control. Core Platform Architecture & Capability Matrix 1. Sovereign Ledger & Ev...
Sara Sheikhlary· Zenodo (CERN European Organi...· 0 citations
Abstract Accurate protein structure prediction does not necessarily identify the conformational state relevant to a specific biological or pharmacological function. In practice, structural biologists often resolve this ambiguity by drawing on homologous, family-related or ligand-bound reference structures, but this pro...
Rui Li· Zenodo (CERN European Organi...· 0 citations
N-K SCIENCES INTERNATIONAL PUBLICATION THE APPLIED N-K FRAMEWORK — COMPLETE ENGINEERING SOLUTIONS Zero-Decoherence Semiconductors · Noor-Insulated Superstrong Materials · Deterministic Drug Discovery · ATP Synthase as Dimensional Rotor · Protein Folding Without Misfolding · The 2026 Innsbruck Confirmation Document ID:...
Muhammad Usman Malik· Zenodo (CERN European Organi...· 0 citations
This study investigated the effect of caffeinated Arabica and decaffeinated coffee lyophilizate (0.6 g/100 g), incorporated either before or after fermentation, on the phenolic compound profile, caffeine and diterpene content, antioxidant activity, and physicochemical properties of yogurt during 20 d of refrigerated st...
Aleksander Siger, D. Cais-Sokolińska, P. Bielska et al.· Journal of Dairy Science· 0 citations
Reliable evaluation of antimicrobial peptide (AMP) predictors is complicated by train-test sequence-similarity leakage and mismatched comparisons with strong protein language model baselines. We present a leakage-controlled framework that quantifies auxiliary-modality value through zero-initialized residual corrections...
Ming-Jian Zhang, Guo-Dong Li, Ying Chang et al.· IEEE transactions on computa...· 0 citations
Metal binding proteins are central to HA pathogenesis, influencing oxidative stress, mitochondrial function, and extracellular matrix remodelling, and these findings provide potential biomarkers and therapeutic targets for synovial-targeted regulation of metal ion homeostasis in HA.
Li-Yin Liu, De-Fu Yu, Da-Sheng Luo et al.· Haemophilia· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
