protein folding

Mechanistic Characterization of NABi as a Selective Inhibitor of SOD1G93A Aggregation: Structural Basis and Therapeutic Implications for ALS

These findings establish NABi as a promising therapeutic candidate for SOD1G93A-associated familial ALS, demonstrating its capacity to selectively target pathological protein conformations while preserving normal cellular function.

DNA Molecular Robot for Osteosarcoma Therapy and Bone Regeneration

A DNA molecular robot that converts tumor microenvironment and near-infrared stimuli into integrin-mediated mechanical forces, generating microtubule-targeting activity without drugs is developed, providing a nonpharmacological strategy for dual-functional implants with synergistic antitumor and osteogenic activities.

Three hydrophobic surface binding a proteins link surface hydrophobicity to sporulation, biofilm formation, and host interaction in Mucor lusitanicus

Results show that HsbA proteins in Mucor lusitanicus function as regulators that couple fungal surface remodeling with developmental transitions, thereby coordinating environmental adaptation and host–pathogen interactions.

Serum SERPINA3 as a Candidate Non-Invasive Biomarker for Neuromyelitis Optica Spectrum Disorder: Proteomic Discovery and Same-Center Validation

SERPINA3 is therefore an exploratory adjunctive serum biomarker candidate rather than a stand-alone diagnostic test; prospective external validation in clinically representative cohorts is required.

Folding states of transit peptides and mature peptides in the cytosol: implications for the import-competent state of preproteins.

It is proposed that the faster folding of TPs, relative to downstream MPs, plays an important role in maintaining preproteins in an import-competent state, and that TPs need to fold into a specific conformation to function properly.

Genome-Wide Characterization of the WIP Transcription Factor Gene Family in Soybean and Physiological Responses to Salt Stress

The GmWIP gene family has expanded substantially in soybean relative to previously characterized species and shows genotype-dependent transcriptional responses to salt stress, suggesting that specific GmWIP members are candidate regulators of salt tolerance and warrant further functional investigation.

[Effects of Early Enteral Nutrition After Total Gastrectomy for Gastric Cancer].

This study demonstrates comparable and in some key indicators higher clinical and economic efficiency of domestic enteral nutrition products in perioperative period for cancer patients with nutritional disorders.

Isolate-Specific Modulation of Growth, Carbon Allocation, and Transcriptomic Responses in Spirodela polyrhiza by Duckweed-Associated Bacteria

Evidence is provided linking bacterial colonization, host transcriptomic regulation, carbon allocation, and biomass production in duckweed, offering a basis for engineering high-performance duckweed–microbiome systems for sustainable biomass production.

Chitosan–cinnamaldehyde–whey protein concentrate stabilized W1/O/W2 double emulsion for co-encapsulation of tea polyphenols and β-carotene

The human papillomavirus L2 protein in the capsid is an ensemble of related structures poised to exit the virus particle

A structural model of L2 within the capsid is developed using cryo-EM single particle analysis of HPV16 pseudovirus capsids with and without the L2 protein combined with AlphaFold3 predictions and molecular dynamics simulations to develop a structural basis for understanding how L2 is organized in the capsid poised to initiate its action during virus entry.

Toward a Minimal Amino Acid Alphabet for Protein Design

The results show that globular proteins may have formed early in evolution and show that it is possible to design proteins with interesting properties for biotechnology and synthetic biology.

Molecular mechanisms of protein disulfide isomerase antagonism by punicalagin.

Biochemical oxidase and reductase assays on PDI showed that punicalagin inhibits both activities with micromolar potency, thereby extending earlier work that described disulfide reductase inhibition.