EL-RAKHAWI NEURO-CONDUCTIVE BIO-PROGRAMMABLE SPIDROIN THREADS (NCBPT)Author: Dr. Mohamed Kamal Arafa El-Rakhawi A paradigm-shifting patent disclosure transcending natural spider silk through three integrated innovations: hybrid protein engineering, AI-guided topological folding, and programmed self-healing—creating int...
mohamed kamal arafa el-rakhawi· Zenodo (CERN European Organi...· 0 citations
Oxidative stress is the condition when there is an imbalance in reactive oxygen species production and the antioxidant defense system. Oxidative stress and neuroinflammation are now widely recognized as two interrelated processes that contribute to neuronal dysfunction and degeneration in neurological disorders. A high...
Vishal Jain· Royal Society of Chemistry e...· 0 citations
Protein phosphatase 2A (PP2A) is a critical regulator of oncogenic signaling pathways, and pharmacological reactivation of PP2A through disruption of inhibitory protein interactions has emerged as a promising anticancer strategy. Although the sphingosine analogue FTY-720 and its derivative OSU-2S can restore PP2A activ...
Rui Yang, Noura Srour, Pankajavalli Thirugnanasambandam et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Rapid advances in protein structure design have not translated to intrinsically disordered regions (IDRs). This is largely due to our incomplete understanding of how IDR sequence encodes function. Here, we use stem cell differentiation as a model to map functional sequence features in the IDR of transcription factor RU...
Lance T. Denes, Ryan J. Emenecker, Nongyun Wang et al.· bioRxiv (Cold Spring Harbor...· 0 citations
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The elucidation of the atomistic structure of PrPSc has, disappointingly, not revealed the mechanism underlying prion propagation. This is because PrPSc has been shown to be a standard amyloid, and as such, it can only template a polypeptide chain that is unfolded. Therefore, while PrPSc can easily template the disorde...
Sanaz Sabzehei, Hasier Eraña, Iria Díaz-Arias et al.· bioRxiv (Cold Spring Harbor...· 0 citations
Rab GTPases are small GTP-binding proteins that play a central role in the regulation of vesicular traffic in all eukaryotes. Pluricellular eukaryotic organisms exhibit an increasing number of Rab GTPase-encoding genes, which may correlate with organismal complexity. However, the genome of the parasitic protist Entamoe...
Naurú Idalia Vargas-Maya, Jennifer Isabel López-Pérez, José A. Martínez-Álvarez et al.· Frontiers in Chemical Biolog...· 0 citations
Industrial biocatalysis relies on the cost effective production of active enzymes in heterologous hosts, yet a substantial fraction of candidate sequences fails during recombinant expression because sequence-level determinants of translational efficiency are not captured by conventional codon optimization alone. Here w...
Tanushree Jaitly, Nicholas R. Silvaggi, Harry R Horn et al.· bioRxiv (Cold Spring Harbor...· 0 citations
By treating each of the 240 E8 root vectors as a phi‑scaled harmonic oscillator at the 132 Hz base frequency, we find that the 16 chord families correspond to resonant modes that drive directed protein folding pathways. The phi coupling induces a self‑similar scaling of the root vectors, producing a discrete set of 12...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Abstract Recognition of N6-methyl-adenosine (m6A) in the RNA sequences by the YT521-B homology domain-containing protein family paralogs 1–3 (YTHDF1–3) is a dominant layer of myriad cellular regulation. Dysregulated YTHDF paralog expression and activities have been reported in cancer, including glioblastoma multiforme...
Abstract Cell-penetrating peptides (CPPs) remain a leading nonviral strategy for the intracellular delivery of polynucleotides and folded proteins, but native α-peptide CPPs are constrained by proteolysis, dose-dependent cytotoxicity, and endosomal entrapment. Peptidomimetic redesign addresses these limitations by repl...
Protein misfolding diseases arise from topological phase transitions in the E8 fiber bundle where non-trivial holonomy around closed loops in configuration space creates wall crossings that trap proteins in pathological configurations. The 240 root vectors define "stability chambers" in fold space, and disease states o...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Mixed bacterial infections, including Gram-positive and Gram-negative pathogens, remain a major global health concern. Achieving efficient treatment of synergistic polymicrobial infections stills a tremendous clinical challenge due to antibiotic permeability barriers and resistance. Here, we construct a defect-engineer...
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
