protein folding

Integrated Strategy for Sustainable Outdoor Photo-Fermentative Biohydrogen Production: Sequential Optimization, Repeated-Batch Operation, Modular Bioreactor Simulation, and Biomass Valorization

This study developed an integrated strategy for outdoor photo-fermentative biohydrogen production by Rhodopseudomonas pentothenatexigens KKU-SN1/1 through low-cost medium optimization, repeated-batch operation, modular bioreactor simulation, and biomass valorization. A sequential experimental design combining one-facto...

Associations of the single nucleotide polymorphism rs2228145 of the IL6R gene with features of the clinical course of hypertrophic cardiomyopathy

Introduction. The study of modifiable cardiometabolic risk factors (CMRFs) influencing the clinical phenotype of hypertrophic cardiomyopathy (HCM) is currently relevant. It is known that modifier genes can affect the course and progression of symptoms in HCM. At the same time, the analysis of associations between si...

Structural and functional insights into the recombinant PR-10 tomato allergen Sola l 4.02

Abstract Sola l 4.02 is a major tomato allergen of the PR-10 family and a Bet v 1 homolog implicated in pollen–food cross-reactivity, yet its molecular properties remain poorly defined. Here, we report the recombinant production and its comprehensive structural and functional characterization. Sequence and structural a...

ArcRefine improves de novo binder designs while preserving binding modes

De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...

Biochemical classification and structural insights into snake venom proteins and peptides

Novel Microparticulation of Pea Protein: Structural Transformation, Enhanced Gelation, Dispersion Stability, and Off‐Taste Masking

Pea protein isolate (PPI) suffers from poor solubility, weak gel‐forming ability, and undesirable sensory attributes that limit its wider adoption in plant‐based food products. This study reports a novel three‐stage process for producing plant protein microparticulate by combining pH shift, high‐pressure homogeniza...

Photoactive Chiral Nanoneedles for Site-Selective Cleavage and Broad-Spectrum Inactivation of Viruses

Respiratory viruses spread through aerosols and contaminated surfaces, yet masks, respirators, and filters only trap pathogens without inactivating them, turning used protective equipment into a secondary transmission source. Here, we report chiral ZnO nanoneedles (L-NNs or D-NNs), stabilized by L- or D-phenylalanine...

Chromo domain proteins: Forms and functions

ProDiPA: Offline Multi-Teacher Distillation and Pareto Alignment for Protein Generation

Overview. This Zenodo record is the compact public-release view of the UniRef50-MultiProp (U50-MP) dataset: a homology-partitioned protein sequence collection with predicted structural confidence, solubility, and thermophilic propensity annotations. It does not rebuild, re-filter, re-cluster, re-split, or re-score any...

Ultrathin Protein Films Create Living Catalytic Interfaces on Microbial Cells

Spatial organization underpins efficient multistep catalysis in nature, yet recreating such organization on living cell surfaces using mild, enzyme-compatible and catalytically functional materials remains challenging. Here we report an l-cysteine-triggered silk fibroin/lysozyme ultrathin film (SLF) that assembles di...

Integrating physiological and proteomics signatures for understanding drought, salinity and alkalinity stress tolerance mechanisms in lentil

Abiotic stresses—such as drought, salinity, and alkalinity severely limit global lentil production by impairing physiological processes including osmolytes accumulation, chlorophyll synthesis, H 2 O 2 production and antioxidant activities. However, no proteomic signature studies have dissected the molecular mechanisms...

Graph Neural Network Modelling of Pre-Diagnostic Serum Proteomics for Pancreatic Cancer Detection

Background/Objectives: Pancreatic ductal adenocarcinoma (PDAC) has exceptionally high mortality, largely because of late diagnosis, while established blood biomarkers such as CA19-9 have limited sensitivity for early detection. We evaluated whether modelling serum proteomic measurements as supervised pairwise statistic...