Category
2,347 papers
Inspired by the protein–vitamin interactions reported in the literature, the present work explored three vitamin B complexes, viz., vitamins B1, B6 and B12, and separately investigated their amyloid inhibitory activities on insulin, showing the considerable amyloid inhibitory activity of thiamine on insulin aggregation...
Salivary neuropeptide Y, interleukin-18 and malondialdehyde are independently associated with periodontitis, whereas salivary tight junction proteins track disease severity without independent association, consistent with downstream barrier injury.
A colorimetric/chemiluminescent vertical flow immunoassay (VFI) for Brucellosis was developed using glutathione-protected cobalt–gold nanoclusters conjugated with staphylococcal protein A (GSH@Co–AuNCs–SPA) as multifunctional catalytic immunoprobes. The nanocluster probe integrates antibody recognition with peroxidase-...
This work developed PanRes, a curated resistance database of 11,717 genes integrating acquired and latent determinants of antibiotic, biocide, and metal resistance within a unified ontology, and predicted representative protein structures and clustered them by structural similarity.
Reach audiences
Advertise in front of researchers, engineers, and readers.
Alpha/Beta hydrolase fold-containing protein; Leishmania infantum (strain JPCM5)
Abstrak Latar belakang. Sindroma Down (SD) adalah aneuploidi autosomal viabel tersering pada manusia dan penyebab genetik utama disabilitas intelektual. Sekitar 95% kasus berupa trisomi 21 bebas (47,XX/XY,+21), yang berakar pada satu peristiwa sitologis: kegagalan pemisahan kromosom 21 saat gametogenesis atau pembelaha...
Collagen, the most abundant protein in the extracellular matrix of mammalian cells, is a key biomaterial in various biotechnological and therapeutic applications, such as tissue engineering and regeneration, cosmetics, and cultivated meat. Despite the increasing demand for culture-based collagen, it is still mainly p...
The enzymatic synthesis of flavor esters is often limited by poor interfacial mass transfer and water-induced equilibrium constraints in conventional systems. Herein, we report a food-grade magnetic Pickering interfacial biocatalysis (PIB) platform based on sodium caseinate (NaCas)–Fe2O3 nanoparticles for accelerated...
Thermophilic bacterial lipases must combine structural stability with the conformational flexibility required for interfacial activation, yet the local organization of their metal-binding sites remains incompletely understood. Here, we determined two X-ray crystal structures of the family I.5 lipase from Geobacillus ka...
Postsurgical distant metastasis remains the leading cause of breast cancer-related mortality, yet reliable biomarkers for identifying patients at high risk of recurrence are lacking. Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) and tumor-associated macrophages (TAMs) contribute to an immunosuppressive...
Abstract Purpose: Limited central nervous system (CNS) bioavailability and pharmacodynamics are obstacles to effective systemic therapies for glioblastoma (GBM). One strategy to overcome these challenges is drug combinations enhancing CNS penetration and/or tumor chemosensitivity. LP-184 (zirdafulven), a synthetic acyl...
A unified physics‑based framework for macromolecular refinement , Predictor and mutational scanning. Built around a novel Self‑Organised Criticality (SOC) controller, it refines proteins, DNA, RNA, and their complexes using a fully differentiable energy function powered by OpenMM, then scales to thousands of in silico...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
