Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Abstract

Highlights • HPV infection primarily targets epithelial cells, escalating with disease progression.• HPV enhances malignant cell communication, fostering an immunosuppressive microenvironment.• Three core gene modules linked to immune evasion and malignant proliferation identified.• An eight‑gene prognostic model predicts survival and immunotherapy response in cervical cancer.