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268 papers
Evaluating critically how historical nosology, molecular pathology and emerging gene-directed interventions relate to one another is evaluated, and to determine which conclusions the accessible evidence can currently sustain are evaluated.
The author did an excellent job of explaining these technologies in language that anyone could understand, and showing why they are important and relevant by giving specific examples, and I thought Wild did an excellent job of explaining these technologies in language that anyone could understand.
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Fusarium wilt, caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense, remains the principal constraint on banana production, particularly for the widely cultivated cultivar ‘Prata-Ana’ (AAB) in Brazil. Given the limited efficacy of conventional control strategies, susceptibility (S) genes have emerged as promising targets for developing resistant cultivars. This study investigated the expression of the banana DMR6 gene during the interaction with Foc. DMR6 was selected because it is a conserved plant susceptibility gene that negatively regulates salicylic acid-mediated immunity, making it a promising target for genome editing. Banana plantlets were inoculated with Foc Subtropical Race 4 under controlled conditions. Temporal expression of the banana DMR6 gene was analyzed by RT-qPCR, and host defense responses were assessed by histochemical and microscopic analyses. DMR6 expression initially decreased and subsequently increased, reaching a 6.5-fold induction at 72 h post-inoculation relative to non-inoculated controls. This expression peak coincided with spore formation and advanced vascular colonization. Although infected roots exhibited callose deposition and phenolic compound accumulation, these defense responses were insufficient to restrict pathogen progression, resulting in severe disease symptoms and a disease severity index of 80% at 90 days after inoculation. The findings indicate that banana DMR6 functions as a negative regulator of plant immunity and is closely associated with susceptibility to Fusarium wilt. These results provide a molecular basis for future functional validation and support DMR6 as a potential target for precise genome editing to develop resistant banana cultivars.
SunTag-NOVA robustly installed DNA methylation and repressed transcription at the endogenous FWA, FT and TMM genes with minimal genome-wide off-target consequences, and establishes SunTag-NOVA as a specific epigenome-editing platform for plants.
It is shown that Cedar virus does use mRNA editing, but at an unusual sequence and by inserting either an adenine or a guanine nucleotide and generating a previously unknown protein, termed U, that shares selected features with the V and W proteins of other henipaviruses.
ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation, genetic predisposition, and lifestyle‐related risk factors. This review aims to provide a comprehensive overview of the epidemiology, pathophysiology, risk factors, and emerging therapeutic approaches for CVD, highlighting recent advances in precision medicine and phytotherapy. Methods A comprehensive literature search was conducted using PubMed, ScienceDirect, and Google Scholar databases. Keywords included “cardiovascular disease,” “Atherosclerosis,” “Pathophysiology,” “Risk Factors,” “Treatment,” “Hyperglycemia,” and “Hypertension.” Approximately 300 publications were initially identified. Following title, abstract, and full‐text screening, 156 relevant articles were selected for inclusion. About 85% of the reviewed literature was published between 2020 and 2025, while the remaining 15% originated from 2016 to 2019. Results The review demonstrates a substantial increase in the global burden of CVDs, with prevalence nearly doubling between 1990 and 2019 and mortality continuing to rise worldwide. Atherosclerosis emerged as the primary pathological basis of ischemic cardiovascular disorders, driven by endothelial dysfunction, oxidative stress, inflammatory cytokines, and vascular remodeling. Major modifiable risk factors include hypertension, smoking, diabetes, dyslipidemia, obesity, unhealthy diet, alcohol consumption, and physical inactivity, while age, sex, and genetic susceptibility contribute to disease risk. Emerging therapeutic strategies such as PCSK9 inhibitors, dual SGLT1/2 inhibitors, siRNA‐based therapies, CRISPR/Cas9 genome editing, and anti‐inflammatory biologics show promising clinical outcomes. Additionally, medicinal plants including Astragalus membranaceus, Citrus bergamia, Hibiscus sabdariffa, and Olea europaea exhibit cardioprotective effects. Conclusion CVD remains a significant global health challenge requiring multifaceted management strategies. The integration of conventional pharmacotherapy, precision medicine, gene‐based interventions, and evidence‐based phytotherapeutics offers promising opportunities to improve cardiovascular outcomes and reduce the growing global disease burden.
A prioritized roadmap for integrating AI into early clinical xenotransplantation is presented, based on clinical need, data availability, technical readiness, feasibility of clinician‐supervised implementation, and potential impact on graft assessment and safety monitoring.
A structured translational roadmap is proposed that prioritizes biologically predictive design, fit-for-purpose safety assessment, scalable good manufacturing practice production, early regulatory alignment, and clinically meaningful benefit over unnecessary structural complexity.
Results suggest that MDM2 3’UTR elongation may trigger a non-canonical regulatory mechanism that bypasses the traditional MDM2-p53 interaction, and suggests that APA-mediated gene modulation can induce unforeseen compensatory survival pathways in cancer cells, necessitating further investigation into the broader functional landscape of elongated 3'UTRs.
Human-Computer Interaction and Visualization
A new algorithm learns to anticipate the unprecedented scenarios that critical infrastructure and global supply chains are least prepared for.
Generative AI
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
In his latest book, Professor Eugene Fitzgerald examines the forces that turn breakthroughs into value — and why innovation resists simple formulas.
General Science
