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257 papers
This work proves that ancient proteins can be reliably recovered from highly degraded palaeogenomic material, establishing a new computational avenue for evolutionary and biochemical research.
Peripheral blood mtDNA-CN is independently associated with cardiac diastolic function in hospitalized older adults, with a more pronounced association in frail individuals.
Results suggest that CRB-701 may be a promising alternative therapeutic for the treatment of nectin-4 expressing tumors, providing a more favorable therapeutic window and potentially enabling regimens with higher doses and less frequent dosing than are required for EV, the only currently approved nectin-4 targeting ADC.
EvoMax is established as an integrated strategy for engineering compact eukaryotic Fz2 genome editors and FanzMAX v3-hLa is identified as a high-efficiency programmable nuclease for mammalian genome editing.
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The LSN-based mild solubilization and chromatographic purification process developed in this study successfully circumvents the destructive effects and complex refolding steps associated with conventional strong denaturants, and the prepared recombinant His-VP1 protein possesses the potential to serve as a high-quality serological diagnostic antigen.
Photodynamic inactivation (PDI) offers a green, non-thermal and sustainable strategy for controlling foodborne pathogens and spoilage microorganisms in animal-derived foods, and natural products are increasingly being explored as photosensitizers. Here, we identify the previously underexplored photodynamic antibacterial activity of the natural alkaloid cepharanthine (CEP). SOSG fluorescence increased 6.88-fold after 10 min of irradiation, suggesting that CEP-mediated bacterial inactivation was predominantly associated with 1O2. Viable-count assays showed that CEP completely inactivated Staphylococcus aureus and Pseudomonas aeruginosa within 40 and 60 min, respectively. Its PDI activity was retained in 10% reconstituted milk without significant changes in pH or lipid oxidation. Incorporation of CEP into gelatin (Gel) films improved ultraviolet shielding, water-vapour barrier properties and mechanical strength. When applied to pork at 4 °C, CEP-Gel films markedly suppressed microbial growth, limiting total viable counts to 4.65 log CFU/g on day 12 compared with 7.50 log CFU/g in the control group. The films also delayed increases in pH, TVB-N, TBARS and weight loss. CEP-Gel significantly delayed microbial growth, lipid oxidation and protein degradation during the 12-day refrigerated storage period. Overall, this study expands the functional scope of CEP and establishes a promising strategy for the sustainable preservation of animal-derived foods.
HRP/Eo crosslinking method is identified as a favorable strategy for engineering dECM particle–THA hydrogels for cartilage regeneration and improved mechanical performance and chondrocyte redifferentiation effect compared to SPS/Ru, attributed to the difference in hydrogel morphology.
The PTM‐related six‐gene model showed potential for prognostic stratification and characterization of immune‐related features in LUAD and demonstrated that the low‐risk group may be more likely to benefit from immunotherapy.
A strategic platform that combines a novel ultrasensitive magnetic resonance (MR) contrast agent with deep learning to significantly enhance the tumor‐to‐normal ratio (TNR) and enabled the reconstruction of three‐dimensional tumor models, offering clinicians an intuitive visualization of tumor structure for precise diagnosis and surgical guidance.
Deep proteomic profiling of human carotid plaques identifies molecular signatures of symptomatic atherosclerosis that extend beyond conventional histopathology, which implicate neutrophil activation and inflammatory signaling pathways as key determinants of plaque vulnerability.
The 1H, 13C, and 15N resonance assignments of the Amblyomin-X Kunitz domain obtained by multidimensional NMR spectroscopy provide the first detailed NMR characterization of the Amblyomin-X Kunitz domain l.
A protein CT analysis plugin for PyMOL v3.6.1 with a graphical user interface (GUI), automatic installation, and novel features developed through integration with PyMOL’s application programming interface (API).
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease