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2,214 papers
This work introduces PROTEAN, a standardized benchmark for text-guided protein structural editing and provides an open testbed for developing autonomous, multi-backend macromolecular design agents.
Fluoride contamination is a long-standing persistent environmental issue, and the silkworm (Bombyx mori) has been recognized as superior as a model organism for toxicological studies. When exposed to fluoride, silkworms can accumulate twice the fluoride content of ingested mulberry leaves. Growth and development are se...
Results indicate that CdtB is involved in E. albertii cytotoxicity against protist hosts, particularly Tetrahymena, and suggest that the cytotoxic mechanism, especially its interaction with host cells, differs from that in mammalian cells.
Findings provide insights into the physiological and proteomic changes during natural stratification that are associated with progressive dormancy alleviation in T. chinensis var.
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Precision fermentation is a key technology for the future sustainable production of food proteins, bulk ingredients, and high-value recombinant products. However, process efficiency is often limited by the coupling of biomass formation and recombinant protein synthesis, leading to substantial carbon losses into non-rec...
Mining environmental metagenomics data, the authors show that small HK97-fold-encoding viral genomes bridge Duplodnaviria viral capsids and cellular protein shells, revealing bidirectional evolution in which viral procapsids enable the transitions between viral and metabolic compartments.
This work introduces a structured-evidence inference paradigm that retains heterogeneous biological observations as modular, named, and experimentally perturbable records rather than compressing them before prediction, and establishes structured biological evidence as a portable interface between heterogeneous biologic...
UGme is presented, a modular, open-source Python package for constructing and validating generalized master equations (GME) models that explicitly account for these non-Markovian (memory) effects of biomolecular processes.
These findings support the established model in which crystallin aggregation is decoupled from global destabilization: although the oxidative modification at W163 is structurally tolerated through rearrangement of the local hydrogen bond network, the resulting changes in backbone flexibility render aggregation-competen...
Anaerobic ammonium oxidation (anammox) is central to low-carbon nitrogen removal, but its engineering application remains vulnerable to environmentally induced oxidative stress, whereby excessive reactive oxygen species (ROS) accumulation damages functional proteins and disrupts proteostasis. Here, we developed a low-c...
We present an all-printed immunosensing microchip that integrates hydrophilic-hydrophobic patterning, covalent antibody immobilization, and photonic bandgap engineering into a single, scalable manufacturing platform for high-sensitivity protein detection. By precisely matching the microchip's photonic bandgap (centered...
This study engineered a series of glycosidase guanine base editor (gGBE) constructs by inlaying the N-methylpurine DNA glycosylase (MPG) domain into Cas9 protein and generated zebrafish models carrying mutations homologous to human amyotrophic lateral sclerosis (ALS)-associated variants.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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