Skip to content
Open access

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

Aug 2026 · CNS Neuroscience & Therapeutics · Vol 32 · 0 citations · 39 references
Medicine

TL;DR

This study investigated the role of Sptbn2 in post‐stroke cognitive impairment (PSCI) and the mechanisms regarding m6A and found that m6A facilitates functional recovery following ischemic stroke.

Abstract

N6‐methyladenosine (m6A) facilitates functional recovery following ischemic stroke (IS). This study investigated the role of Sptbn2 in post‐stroke cognitive impairment (PSCI) and the mechanisms regarding m6A.

Read PDF

Similar papers

Open access Oct 2026

Mitochondrial YME1L Restrains GRP75-Dependent ISR Activation to Prevent Podocyte Senescence in Diabetic Kidney Disease.

ARTICLE HIGHLIGHTS Loss of YME1L promotes podocyte senescence in diabetic kidney disease. YME1L deficiency induces sustained maladaptive integrated stress response activation. YME1L interacts with and regulates mitochondrial GRP75 homeostasis. GRP75 accumulation drives persistent integrated stress response activation a...

Qian-Qian Yang, Yi-Yuan Zhang, Yao-Wu Zhang et al. · 0 citations
Open access Sep 2026

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Microglia‐mediated clearance of amyloid beta (Aβ) is crucial for mitigating Alzheimer's disease (AD) progression, yet the molecular regulators of microglial phagocytosis remain incompletely understood.

Jian Meng, Yong Wang, Jing-Hui Wang et al. · 0 citations

Targeting an RNA-binding protein to fight aging

PUM2 expression increases upon aging and this facilitates the capture/trapping of Mff mRNA, either alone or in association with other RNA-binding proteins (RBPs) in Ribonucleoprotein particles (RNP).

Unknown authors · 0 citations
Sep 2026

Targeting CH25H restores p62-mediated α-synuclein clearance.

Astrocytes remove extracellular α-synuclein aggregates through p62-dependent autophagy, yet the factors limiting this defense remain unclear. Zhang and colleagues recently identified cholesterol 25-hydroxylase as an inducible negative regulator of p62-mediated clearance. Genetic suppression or a p62-derived decoy pepti...

G. S. Dawe · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.