Results identify Cryaa as a critical regulator of ER stress and demonstrate that its reduction promotes UPR activation and subsequent photoreceptor apoptosis in the rd9 model, revealing a key role for Cryaa in XLRP pathology and may provide a novel therapeutic perspective for this disease.
Ming-Zhu Yang, Rui-Qi Qiu, S. Yao et al.· Cell Death & Disease· 0 citations
ABSTRACT Microplastics (MPs) accumulation in ecosystem and human organs poses urgent environmental and health risks, yet few enzymes efficiently degrade polyethylene terephthalate (PET) under physiological conditions. We leveraged deep learning to mine unexplored sequence space across 246 million proteins, discovering...
Yuxuan Wang, Shijie He, Yuheng Chang et al.· Advancement of science· 0 citations
SIRT1–GAPDH signaling represents a post-translational axis linking sirtuin activity directly to glycolytic enzyme function, distinct from SIRT1's traditional transcriptional roles and serving as a viable molecular checkpoint in microglial immunometabolism.
Chou-Yi Hsu, I. Sapaev, O. Nematov et al.· Frontiers in Immunology· 0 citations
The results suggest that roles of CetZ1 in cell shape or potentially the organisation and structure of the cell poles influence the polar assembly of the motility machinery.
Hannah J. Brown, Md Imtiazul Islam, J. Ruan et al.· Molecular Microbiology· 0 citations
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Structural and biochemical studies have elucidated the architecture of the nsp14 N7-methyltransferase domain, revealing an S-adenosyl-L-methionine (SAM)-dependent fold with a defined cofactor-binding site and an adjacent cap-binding pocket that orients the RNA substrate for methyl transfer.
Yifan Zhao, Rhea Guo, Yang Yang et al.· Microorganisms· 0 citations
The temporal decline of circulating miR-1-3p levels and the identification of PKC support a model in which miR-1-3p may contribute to functional maturation of the ZR through modulation of non-canonical intracellular signaling pathways.
Jani Liimatta, Emre Murat Altınkılıç, Therina du Toit et al.· Journal of Clinical Endocrin...· 0 citations
The data demonstrate that MRO is poised to play a role in the coordination of periovulatory events through the EGF and progesterone signaling pathways through the EGF and progesterone pathways.
Ketan Shrestha, Patrick R. Hannon, M. Wynn et al.· Biology of Reproduction· 0 citations
A cheap density prior is introduced over natural protein activations and keeps only the candidates that remain typical under it, a training-free post-hoc step the authors call Mahalanobis filtering that improves both the property score and the structural plausibility of the sequences it keeps at negligible cost, withou...
Shuibai Zhang, Xin-Chi Liu, Fred Zhangzhi Peng et al.· 0 citations
3D models of the C-terminal SC region suggest that the major C-terminal domain of SC folds into a single-layer β-sheet structurally similar to the membrane occupation and recognition nexus (MORN) family of tandem repeats, which is critical for understanding SC-mediated fibrin generation.
Pablo Fuentes-Prior, A. Maddur, Peter Panizzi et al.· Biological chemistry· 0 citations
This study investigated the synergistic effects of supercritical carbon dioxide (SCCD) combined with sucrose treatment on the foaming properties and freeze-thaw stability of egg white protein (EWP). The results demonstrated that SCCD-sucrose treatment significantly enhanced the foaming capacity, achieving a maximum...
Lixian Ding, Minquan Xia, Xinyue Zhang et al.· Food Science of Animal Produ...· 0 citations
A divergent regulation of CD29 and CD49b integrins associated with HLA-B27 status in Iraqi AS patients is suggested and longitudinal validation is required to confirm their clinical utility as diagnostic or therapeutic targets.
Ahmed Ali Alshammari, M. Mohsin· Iranian Journal of Pathology· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
