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334 papers
It is suggested that biogenically synthesized MgO NPs hold considerable promise as antibacterial and antibiofilm agents against MDR Gram-negative pathogens.
This study provides the first report of negative chemotaxis responses in S. meliloti and provides the first description of negative chemotaxis in S. meliloti's chemotaxis to dipeptides.
This study provides a practical framework for creating intrafilamentary porosity into 3D-printed PCL scaffolds with improved surface-mediated biological performance.
The findings indicate that an increase in oxidative stress parameters arose at the earlier phase of ischemic neurodegenerative processes, while SREBP-1 expression increased in the mid-phase.
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Pathway analysis revealed that TNRC6A predominantly regulates RNA processing and miRNA-mediated silencing, whereas TNRC6B modulates the mitogen-activated protein kinase and inflammatory responses, indicating that TNRC6A and TNRC6B function cooperatively and distinctly in miRNA-mediated gene regulation.
It is found that heat-induced CHH methylation targets specific genomic loci in a developmental stage-specific manner, with a differentially methylated window located within 6 kb of AT5G44410, an F-box protein-encoding gene.
It is shown that DBD alone produces dose-dependent repression of DUX4-FL transcriptional activity in HEK293T cells, while a constitutively expressed DBD-KRAB fusion produces significantly greater repression than DBD alone, with a similar trend observed in C2C12 myoblasts.
A glycan-dependent chaperone network is defined, finely tuned by a combination of low-micromolar interactions between the constituents, that ensures efficient MHC-I maturation and illustrates fundamental principles of ER protein quality control.
A previously unrecognized mechanism regulating RNase activity in a dicot PM RALPH effector is revealed and new insights are provided into the functional diversification of RALPHs and their adaptation to obligate biotrophy.
Biochemical evaluation of triazinone 3 revealed significant reductions in acetylcholinesterase activity and in total protein, carbohydrate, and lipid contents compared with untreated larvae, indicating that larval mortality was accompanied by cholinergic disturbance and depletion of metabolic reserves.
A testable positive-feedback perspective in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another is proposed, in which thyrocyte ERS injury and immune effector amplification may mutually reinforce one another.
A DDP-doped black phosphorus (BP) nanomedicine protected by polydopamine coating that synergistically delivered DDP and piezoelectric BP to precisely disrupt resistance homeostasis and thereby reverse DDP resistance is established.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease